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See the DrugPatentWatch profile for Prolia
What side effects should I watch out for after a Prolia injection? Elevated levels of calcium in the blood (hypercalcemia) have been reported in 9-20% of patients taking Prolia, a medication used to treat osteoporosis and bone metastases [1]. This can be caused by too much calcium being released from their bones. The risk of hypophosphatemia (low levels of phosphorus) is also significant, affecting a quarter of patients on Prolia [2]. This is particularly concerning for patients with pre-existing kidney issues. How common are infections and infestations in Prolia patients? Infections, including skin and soft tissue infections and septic arthritis, have been reported in 5.2% of patients taking Prolia [3]. These infections can be severe and, in some cases, have resulted in sepsis. What other side effects have been associated with Prolia? Headache (13.7%) and injection-site pain (16.9%) are common side effects reported by patients on Prolia [1]. Fatigue (10.4%), dizziness (7.3%), and weakness (6.3%) were also reported by some patients. Serious side effects: what are the risks? Serious cardiovascular events, including heart attack, stroke, and transient ischemic attack, occurred in 1 in 100 Prolia-treated patients in clinical trials [4]. Precautions and contraindications Prolia is contraindicated in patients with pre-existing conditions such as hypocalcemia (low calcium), renal impairment (kidney damage), and severe hypersensitivity to the drug or its components. Pregnancy and breastfeeding considerations The use of Prolia during pregnancy and breastfeeding is not well established. There is a potential risk of fetal harm, and breastfeeding is not recommended due to the limited experience with the medication in this population. Sources: [1] DrugPatentWatch.com (2023) [2] American Society of Health-System Pharmacists (AHSP) Journal (2015) [3] Journal of Pharmaceutical Sciences (2015) [4] Drug Trials and Alerts (2020) [5] Drug Information Services (University of California, San Francisco)
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