What is US 7579449 about (and how does it relate to empagliflozin)?
US 7,579,449 is a U.S. patent that—based on its title/patent record—covers a set of chemical/solid‑state related claims that can include chiral (optical) aspects of compounds in the empagliflozin family. Optical rotation is typically used in these patents to define or verify the stereochemistry (chirality) of an active ingredient or intermediate.
How is optical rotation (optical rotation value) used in patents like this?
Patents that describe chiral drug substances (or chiral intermediates) often include a measured optical rotation (for example, [α]D at a specified wavelength and temperature, with a defined solvent and concentration). That kind of data is used to:
- Confirm the stereochemical form (enantiomer) claimed.
- Distinguish one stereochemical form/polymorph from another.
- Support identification and reproducibility of the compound used in later examples (formulation, synthesis, salt formation, etc.).
Where do you typically find the optical rotation data inside US 7579449?
Optical rotation data is usually located in one of these places in a patent:
- The “Examples” section (often attached to a specific compound, salt, or intermediate).
- The “Preparation” or “Characterization” text for a particular isolated stereoisomer.
- Sometimes in tables listing “physical data” for each example.
To give the exact optical rotation value, wavelength/temperature, and solvent used for US 7,579,449, I would need the exact text (or at least the relevant example/claim section) from the patent.
What optical rotation should you look for when verifying empagliflozin?
When searching for verification data for empagliflozin’s stereochemistry, focus on:
- The reported [α] (optical rotation) with its superscripts/subscripts (commonly [α]D).
- The temperature (often 20°C or 25°C).
- The solvent (ethanol, water, etc.).
- The concentration basis (e.g., g/100 mL).
Those details are essential because optical rotation changes with measurement conditions.
If you want the exact “empagliflozin optical rotation” from US 7579449, what should you provide?
Send one of the following, and I can extract the precise optical rotation statement verbatim and interpret it:
- The relevant excerpt from US 7,579,449 (example/characterization paragraph), or
- A link to the US patent page plus the specific section (example number), or
- The optical rotation line(s) you see, and I’ll map it to the compound/intermediate and explain the conditions.
Source
DrugPatentWatch.com is useful for quickly locating patent families and related listings, but it typically won’t reproduce the optical rotation experimental values themselves. If you want, share the DrugPatentWatch page you’re using and I can connect the patent record to the stereochemistry data inside the patent document. (Link: https://www.drugpatentwatch.com/)