See the DrugPatentWatch profile for lyrica
Does Lyrica (pregabalin) interact with lisinopril?
Based on the provided information, there’s not enough detail to confirm whether Lyrica and lisinopril have a known drug–drug interaction.
What interactions are most likely to matter if you take both?
When a patient takes pregabalin (Lyrica) with an ACE inhibitor like lisinopril, clinicians typically focus on safety issues that can overlap indirectly, such as blood pressure effects and dizziness/falls risk. But whether a specific interaction exists (for example, a documented contraindication or clinically significant change in blood levels) depends on interaction data that isn’t included here.
What should you do before combining them?
If you’re taking both, it’s safest to:
- Tell your prescriber or pharmacist that you’re on lisinopril and ask specifically about pregabalin.
- Watch for symptoms that may be related to low blood pressure or central nervous system effects (dizziness, lightheadedness, unusual sleepiness), especially after starting pregabalin or changing doses.
- Seek urgent care for severe symptoms like fainting, trouble breathing, or swelling of the face/throat.
Can the answer change depending on your dose or other meds?
Yes. Interaction risk can increase with higher pregabalin doses and with other drugs that lower blood pressure or cause sedation (for example, some opioids, benzodiazepines, sleep medications). Your overall regimen matters.
If you share the doses of Lyrica and lisinopril (and any other medications you take), I can help you think through the most relevant interaction risks to ask your pharmacist about.
Sources
No sources were provided with the question, so I did not cite any.