Does Lyrica (pregabalin) raise heart rate?
Lyrica (pregabalin) can affect the nervous system and may cause cardiovascular side effects in some people. Product safety information includes reports of changes in heart rhythm and heart rate, including tachycardia (fast heart rate) and palpitations [1].
What symptoms should patients watch for?
People using Lyrica who notice new or worsening cardiovascular symptoms—such as a consistently fast pulse, palpitations, dizziness, fainting, or chest pain—should contact a clinician promptly, especially if symptoms are severe or persistent [1].
Who is more at risk of heart-rate problems?
The risk can be higher in people who already have heart rhythm issues or other cardiovascular conditions, or who are taking other medications that can affect heart rhythm. If you have an underlying cardiac problem, it’s important to discuss it with your prescriber before starting or changing the dose [1].
Could the heart-rate increase be from something else?
Some causes of fast heart rate that occur around the same time as starting or increasing Lyrica may be unrelated—for example, anxiety, dehydration, fever, thyroid problems, stimulant medications, or other drug interactions. Still, because Lyrica can be associated with tachycardia/palpitations, symptoms should be evaluated rather than assumed to be unrelated [1].
Does dose or discontinuation matter?
Heart-rate–related side effects are more likely to occur when dosing changes (starting, increasing, or sometimes when other factors affect drug levels). If side effects occur, clinicians may adjust the dose or consider alternatives [1].
When to seek urgent care
Seek emergency care if fast heart rate comes with red flags such as chest pain, shortness of breath, fainting, or a feeling of an irregular heartbeat with weakness or severe dizziness [1].
Sources
[1] https://www.drugs.com/sfx/lyrica-side-effects.html