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How does lipitor affect lipid absorption?



Lipitor is a medication that is used to lower cholesterol levels in the body. The active ingredient in Lipitor is atorvastatin, which belongs to a class of drugs known as statins. Statins work by inhibiting an enzyme called HMG-CoA reductase, which is involved in the production of cholesterol in the liver [1].

According to a study published in the Journal of Lipid Research, atorvastatin can reduce the absorption of dietary cholesterol in the intestine by up to 50% [3]. This is because statins can reduce the expression of a protein called NPC1L1, which is responsible for the uptake of cholesterol from the diet into the intestinal cells [2].

In addition to reducing the absorption of dietary cholesterol, atorvastatin can also decrease the levels of triglycerides in the blood [1]. Triglycerides are another type of lipid that is associated with an increased risk of heart disease.

Overall, Lipitor (atorvastatin) can lower cholesterol levels in the body by inhibiting the production of cholesterol in the liver and reducing the absorption of dietary cholesterol in the intestine. Lipitor can also lower triglyceride levels in the blood. It is important to note that Lipitor should be taken as prescribed by a healthcare provider and that it may have side effects [1].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/books/NBK430779/
[3] https://pubmed.ncbi.nlm.nih.gov/36419245/



Follow-up:   Does Lipitor inhibit lipid absorption? Can Lipitor reduce cholesterol absorption? How does Lipitor affect fat absorption?





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