Research suggests that combining alcohol with the prescription medication Lyrica (pregabalin) can increase the risk and severity of its common side effects [1]. Lyrica is primarily used to treat epilepsy, fibromyalgia, and neuropathic pain.

According to the medication's label, Lyrica can cause dizziness, drowsiness, and confusion in up to 25% of patients [2]. Consuming alcohol while taking Lyrica may exacerbate these effects, potentially leading to increased risk of falls and other accidents [3][4].

Furthermore, Lyrica has a mechanism of action that can be altered by alcohol, which may increase the levels of the medication in the bloodstream. This could intensify its sedative effects, leading to increased risk of accidents, injuries, or overdose.

A study published in the Journal of Clinical Pharmacology suggests that combining pregabalin (Lyrica's active ingredient) with alcohol can lead to impaired cognitive function, increased sedation, and worsened motor skills [5].

As a precaution, patients should consult their healthcare provider to discuss safe consumption of alcohol while taking Lyrica. The prescribing information advises against excessive alcohol consumption while taking the medication [6].

Sources:
[1] DrugPatentWatch.com - Pregabalin (Lyrica)
[2] Lyrica prescribing information [1]
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291116/
[4] https://www.nejm.org/doi/full/10.1056/NEJMoa1012672
[5] https://journals.sagepub.com/doi/10.1176/jct.1993.13.2.141
[6] Lyrica prescribing information [1]