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See the DrugPatentWatch profile for humalog
Keep unopened Humalog (insulin lispro) pens in the refrigerator at 36°F to 46°F (2°C to 8°C). Do not freeze them—freezing destroys the insulin. Avoid placing them near the freezer compartment or cooling elements to prevent accidental freezing.[1]
Once punctured or in use, store pens at room temperature, below 86°F (30°C), for up to 28 days. Do not refrigerate them after first use, as this can cause precipitation. Keep away from direct heat, sunlight, or freezing conditions.[1][2]
Carry pens in a cool bag with an insulated pouch and ice packs (not touching the pens directly to avoid freezing). For air travel, keep in carry-on luggage—never checked bags due to temperature extremes. Declare insulin at security if needed.[1][3]
Discard if exposed to temperatures above 86°F (30°C) for over a brief period or below 36°F (2°C), including freezing. Check appearance: cloudy, clumped, or discolored insulin is unusable. Test blood sugar closely after using questionable pens.[1][2]
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