Unopened Humalog Vials or Pens
Store at 36°F to 46°F (2°C to 8°C) in a refrigerator. Do not freeze. Keep away from the cooling element. If refrigeration is unavailable, it remains usable for 28 days at up to 86°F (30°C), but discard after that period.[1]
Opened Humalog Vials or Pens
After first use, store at room temperature below 86°F (30°C). Do not refrigerate opened products. Use within 28 days; discard even if product remains. Avoid direct sunlight or heat sources.[1]
Humalog KwikPen Specifics
Same as above: unopened in fridge (2°C-8°C), opened at room temp (<30°C) for max 28 days. Prefilled pens show dose remaining via window; do not use if discolored or cloudy.[1]
Travel and Temperature Excursions
For flights or outings, use insulated bags with gel packs (not frozen solid). Humalog tolerates brief exposure up to 98.6°F (37°C) for short periods, but monitor with a thermometer app or device if possible. Replace if exposed beyond 28 days total at room temp.1
Signs It's Gone Bad
Inspect for clarity (should be clear, colorless); discard if particles, frost, or discoloration appear. Never use frozen insulin.[1]
Patient Tips for Compliance
Mark opening date on carton or use apps like MySugr for reminders. Lilly offers patient support for storage queries via 1-800-LillyRx.2
[1]: https://pi.lilly.com/us/humalog-pi.pdf (Humalog Prescribing Information, Eli Lilly)