Humalog vial expiration after opening?

What determines the shelf life of an opened Humalog vial?

According to the manufacturer, Eli Lilly and Company [1], a vial of Humalog (insulin lispro injection) 100 Units/mL KwikPen and Humalog U-100 100 Units/mL vial can be stored at room temperature (up to 77°F, 25°C) for up to 28 days after initial use.

However, it's essential to note that once an opened Humalog vial is stored in the refrigerator, its shelf life is extended to 28 days. It's also worth mentioning that after mixing Humalog with a diluent, the resulting solution should be used immediately or within 1 hour at room temperature or within 30 hours under refrigeration [2].

What happens if I don't follow proper storage or handling?

Failure to follow proper storage and handling procedures may lead to degradation of the solution, reducing its potency and potentially affecting its effectiveness.

Can I use an opened Humalog vial past the expiration date?

The expiration date on a Humalog vial indicates the last date it was verified to be potent. As long as the vial has been stored and handled properly, it may still be usable even after the expiration date [3]. However, it's crucial to verify the vial's appearance, clarity, and concentration of the solution before use.

How can I ensure the safe use of an opened Humalog vial?

To ensure the safe use of an opened Humalog vial, always check the expiration date and follow the manufacturer's storage and handling instructions.

What if I want to store an opened Humalog vial for a shorter or longer period?

According to Eli Lilly and Company, a Humalog vial can be stored in the refrigerator for up to 28 days after initial use. If you need to store the vial for an extended period, consult with your healthcare professional for guidance.

Can I use Humalog vials interchangeably?

It's essential to use Humalog vials that are within their expiration dates and follow proper storage and handling procedures to ensure the integrity of the solution.

How can I dispose of an expired or damaged Humalog vial?

Expired or damaged Humalog vials should be disposed of according to local regulations and guidelines.

* Humalog U-100 vial [1]
* Eli Lilly and Company. Humalog (insulin lispro injection) 100 Units/mL KwikPen Prescribing Information. https://www.lilly.com/sites/default/files/about_us_us_en/external__pi_/humalog_vial_pi.pdf
* Eli Lilly and Company. Humalog (insulin lispro injection) 100 Units/mL KwikPen Patient Information Leaflet. https://www.lilly.com/sites/default/files/about_us_us_en/external__pii_humalog_vial_patient_information_leaflet.pdf
* Eli Lilly and Company. Humalog U-100 vial. https://www.lilly.com/en/products/humalog/