Can Lyrica (pregabalin) cause depression?
Yes. Lyrica (pregabalin) can cause mood-related side effects, including depression, and it can also worsen existing mood problems in some people. This risk is part of the drug’s known psychiatric side effects.
What other mental health side effects can happen with Lyrica?
Along with depression, people may report changes such as anxiety, agitation, or unusual mood/behavior. In some cases, Lyrica can be associated with suicidal thoughts or behaviors, so mood changes should be taken seriously—especially if they are new, worsening, or severe.
When should someone stop and get help?
Get urgent medical help right away if mood changes come with any of the following:
- thoughts of self-harm or suicide
- severe agitation, confusion, or drastic behavior changes
- signs of serious worsening depression
Does stopping Lyrica suddenly make it worse?
Stopping pregabalin abruptly can lead to withdrawal symptoms and rebound issues in some people. If you’re thinking about stopping because of depression or mood changes, contact the prescriber first for a safe plan to reduce the dose if appropriate.
Who is more at risk?
Risk can be higher if you already have:
- depression or other mental health conditions
- a history of suicidal thoughts/behavior
- recent significant life stressors or worsening mood symptoms
Your prescriber may monitor you more closely or adjust the dose if you develop psychiatric symptoms.
What should you do if you notice depression after starting Lyrica?
- Call your prescriber promptly to report the symptom and how soon it started after beginning or changing the dose.
- Avoid changing the dose on your own.
- If symptoms are severe or you have any suicidal thoughts, seek emergency help.
How long after starting Lyrica can depression show up?
Mood side effects can occur anytime during treatment, including after starting or after dose increases. If depression begins soon after a dose change, that timing is a useful clue for your clinician.
Can depression be from the condition being treated instead?
Yes. The condition Lyrica is prescribed for (such as nerve pain) can affect sleep, stress, and overall wellbeing, which can also contribute to depression. That’s why clinicians consider the timing of symptoms relative to starting or changing Lyrica.
Sources:
1. FDA label for Lyrica (pregabalin) – boxed warnings and adverse reactions including psychiatric effects (including suicidal ideation/behavior). https://www.accessdata.fda.gov/scripts/cder/daf/