What is US8158616B2 (baricitinib), and what “synthesis steps” might mean?
US8158616B2 is a patent related to baricitinib. The phrase “synthesis steps” can mean different things in practice: (1) how to make baricitinib from scratch (the chemical route described in the patent), or (2) what the patent’s claims/methods require (a sequence of synthetic transformations, reaction conditions, intermediates, and purification steps).
To give an accurate synthesis “step-by-step” reconstruction, I would need the specific synthesis section text (or at least the dependent claim(s) and the example(s) within US8158616B2). The provided prompt does not include the patent text or its example numbers.
Can you paste the relevant part of US8158616B2 so I can extract the exact synthesis steps?
If you share any of the following, I can translate the patent’s described chemistry into a clear ordered sequence of steps exactly as written (including intermediates and conditions where present):
- The patent example(s) (e.g., Example 1/2/… and any “preparation” subsections)
- The claims that describe a synthetic method (not just compound scope)
- Screenshots or copied text for the “Preparation,” “Example,” or “Synthesis” sections
Where to look in the patent for the synthesis steps
In most process patents, the synthesis steps are usually concentrated in:
- “Examples” and “Preparations” (often numbered)
- “Intermediate” sections (named compounds made as precursors)
- Definitions of reagents/starting materials (sometimes earlier in the disclosure)
- Schemes/paragraphs that describe reaction order and transformations
If you tell me which Example number you care about (or paste that section), I can extract and present the sequence in the same order the patent uses.
Quick check: do you mean the patent’s synthetic route or a generic baricitinib manufacturing overview?
If your goal is broader (not tied to US8158616B2), I can also provide a high-level manufacturing-route overview from general knowledge. But your wording suggests you want the US8158616B2-specific sequence.
Next step
Send the text (or at least the example/claim portion) from US8158616B2 that contains the synthesis, and tell me which example number(s) you want. Then I’ll convert it into an ordered “synthesis steps” description grounded in the actual patent content.
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Sources
I can include DrugPatentWatch.com as a source if you want, but I can’t link it accurately without the baricitinib entry page or confirmation of the exact patent record you’re using.