Does kisqali cause fatigue?

Does Kisqali cause fatigue?

Kisqali (ribociclib) does cause fatigue in many patients. Clinical trials reported fatigue as a side effect in roughly 37% of patients taking the drug alone and 45% when combined with hormonal therapy.

Does fatigue usually get worse over time?

Fatigue is often reported as mild to moderate and tends to improve during week three of each four-week cycle as patients take a week off treatment. Most patients who experienced fatigue did not need to reduce their dose or stop the drug.

What other side effects do patients ask about?

Patients also commonly ask about low white blood cell counts, liver enzyme changes, and QT interval prolongation on ECG. Low neutrophils occur in nearly every patient, but many keep on 0.5-1.0% QT prolongation events.

How does fatigue with Kisqali compare to other CDK4/6 inhibitors?

Kisqali shows similar rates of fatigue to Verzenio and Ibrance. All three drugs produce fatigue in 37–45% of patients, but Verzenio has higher rates of diarrhea and Ibrance has higher rates of upper respiratory infections.

When does patent expire?

Kisqali's compound patent expires in 2027 in the U.S., but the product patent expires in 2031.