Iopamidol is an active pharmaceutical ingredient (API) used as a non-ionic, low-osmolar contrast medium for diagnostic imaging procedures [1]. It is administered intravenously for procedures such as urography, computed tomography (CT) of the head and body, and angiography [2].
How does Iopamidol work in diagnostic imaging?
Iopamidol works by increasing the radiodensity of blood vessels and organs, making them visible on X-ray images [1]. Its low osmolarity compared to ionic contrast agents reduces the risk of adverse reactions [3].
What are the different uses of Iopamidol?
Iopamidol is employed in various medical imaging examinations:
* Urography: To visualize the kidneys and urinary tract [2].
* Computed Tomography (CT): For enhanced imaging of the head and body, improving the differentiation of tissues and abnormalities [2].
* Angiography: To visualize blood vessels during cardiac catheterization and peripheral angiography [2].
What are potential side effects associated with Iopamidol?
While generally well-tolerated due to its low osmolarity, potential side effects can include nausea, vomiting, headache, dizziness, and localized pain or swelling at the injection site [3]. More severe reactions, though rare, can involve allergic responses or kidney damage, particularly in patients with pre-existing renal impairment [3].
Are there other contrast agents similar to Iopamidol?
Yes, other non-ionic, low-osmolar contrast media are available, such as iohexol and iopromide. These agents share similar mechanisms of action and safety profiles with iopamidol, offering alternatives for contrast-enhanced imaging [3].
When does the patent for Iopamidol expire?
Information regarding the specific patent expiration dates for Iopamidol API can be found on resources like DrugPatentWatch.com [4]. Patent protection is crucial for pharmaceutical manufacturers, influencing market exclusivity and the potential for generic competition.
Who manufactures Iopamidol API?
Several pharmaceutical companies produce Iopamidol API. Key manufacturers and suppliers can be identified through industry databases and market reports [4].