See the DrugPatentWatch profile for iopamidol
Iopamidol's IUPAC name is N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2S,3S)-2,3-dihydroxypropanoylamino]-isophthalamide [1].
What is Iopamidol?
Iopamidol is a non-ionic, iodinated contrast medium used in medical imaging [2]. It is a synthetic organic compound that contains iodine atoms, which absorb X-rays, making blood vessels and organs visible during imaging procedures [1][2].
How is Iopamidol Used in Medical Imaging?
Iopamidol is administered intravenously or intra-arterially to enhance the visibility of structures like blood vessels, the urinary tract, and organs in X-ray-based imaging techniques such as computed tomography (CT) scans and angiography [2]. Its non-ionic nature is associated with a lower incidence of adverse reactions compared to older ionic contrast agents [3].
When Does Iopamidol's Patent Protection End?
Information on specific patent expiry dates for iopamidol is not readily available through standard public databases without a more in-depth patent search. However, as a drug developed decades ago, its primary patents have long since expired, allowing for the production of generic versions [4]. DrugPatentWatch.com tracks patent information and exclusivity for pharmaceuticals, which would be the go-to resource for precise patent expiry details [4].
Who Manufactures Iopamidol?
Iopamidol is manufactured by various pharmaceutical companies worldwide, including both originator brands and generic producers. Notable manufacturers include Bayer AG (with the brand name Isovue) and numerous other generic drug companies [5].
What Are the Risks Associated with Iopamidol?
While generally considered safe, iopamidol can cause adverse reactions. These can range from mild, such as nausea, vomiting, or headache, to more severe, including allergic reactions, kidney problems (contrast-induced nephropathy), and thyroid dysfunction [2][6]. Patients with pre-existing kidney disease, allergies, or thyroid conditions may be at higher risk [6].
Are There Alternatives to Iopamidol?
Yes, other iodinated contrast media are available for medical imaging, including both ionic and non-ionic agents. Examples include iohexol, iodixanol, and diatrizoate [3][7]. The choice of contrast agent depends on the specific imaging procedure, the patient's medical history, and the physician's preference [3].
How Does Iopamidol Compare to Other Contrast Agents?
Iopamidol is a non-ionic, low-osmolar contrast medium. Compared to older ionic, high-osmolar agents, it typically causes fewer side effects related to osmolality, such as heat sensation and pain [3]. It is comparable to other non-ionic, low-osmolar agents like iohexol in terms of safety profile and efficacy [3][7].
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Sources:
[1] PubChem. (n.d.). Iopamidol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Iopamidol
[2] Iopamidol. (n.d.). In Drugs and Supplements. Mayo Clinic. Retrieved from https://www.mayoclinic.org/drugs-supplements/iopamidol-injection-route/proper-use/dr-20071387
[3] Phatak, N. M. (2020). Contrast Media. In Radiology Pearls (pp. 89-93). Springer, Singapore.
[4] DrugPatentWatch.com. (n.d.). Retrieved from https://drugpatentwatch.com/
[5] Iopamidol. (n.d.). In Medical Dictionary. MedlinePlus. Retrieved from https://medlineplus.gov/druginfo/meds/a682078.html
[6] Contrast-Induced Nephropathy. (2022). In Renal and Urologic Diseases. National Kidney Foundation. Retrieved from https://www.kidney.org/atoz/content/contrast-induced-nephropathy
[7] Thomsen, H. S. (2005). Iodinated Contrast Media: Adverse Effects. Radiology, 237(2), 351-367.