Methotrexate is a medication used to treat various conditions such as cancer, psoriasis, and rheumatoid arthritis. It is essential to know which medications interact with methotrexate to avoid any adverse effects or reduced effectiveness of the drug.

According to Drug Patent Watch [1], there are 291 drugs that interact with methotrexate. These drugs include antibiotics, antifungals, anticonvulsants, and immunosuppressants, among others. Some of these drugs can increase the toxicity of methotrexate, while others can decrease its effectiveness.

WebMD [2] states that nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and aspirin can increase the risk of methotrexate toxicity. Other medications that can interact with methotrexate include penicillin, phenytoin, and sulfonamides.

GoodRx [3] also lists several medications that interact with methotrexate. These include corticosteroids, proton pump inhibitors, and some vaccines. Additionally, alcohol consumption can increase the risk of liver damage when taking methotrexate.

It is crucial to inform your doctor of all medications, supplements, and vitamins you are taking before starting methotrexate. Your doctor may need to adjust the dosage or monitor you more closely to avoid any adverse effects.

In conclusion, methotrexate can interact with many medications, and it is essential to inform your doctor of all medications you are taking. Some drugs can increase the toxicity of methotrexate, while others can decrease its effectiveness. It is essential to follow your doctor's instructions and avoid alcohol consumption while taking methotrexate.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/METHOTREXATE
[2] https://www.webmd.com/drugs/2/drug-3441/methotrexate-anti-rheumatic-oral/details
[3] https://www.goodrx.com/methotrexate/interactions