Mannitol is a sugar alcohol commonly used as a sweetener, bulking agent, and osmotic diuretic [1]. It is derived from fructose, typically obtained from corn or wheat [2].
How is Mannitol Made?
Mannitol is produced through the hydrogenation of fructose [3]. This chemical process involves adding hydrogen to fructose under specific conditions, usually with the aid of a catalyst, to convert it into mannitol [3]. Fructose itself is commonly sourced from high-fructose corn syrup or derived from other plant sources like fruits and vegetables [2].
What are the Different Grades of Mannitol?
Mannitol is available in various grades depending on its intended application. Pharmaceutical-grade mannitol is produced under strict quality controls for use in medications, often as an excipient in tablets and capsules, or as an injectable solution for medical purposes, such as reducing intracranial pressure [4]. Food-grade mannitol is used in the food industry as a low-calorie sweetener and bulking agent in products like sugar-free candies, chewing gum, and baked goods [5].
Where Can I Buy Mannitol?
Mannitol can be purchased from various suppliers, including chemical distributors, pharmaceutical ingredient manufacturers, and food additive suppliers [6]. The availability and pricing will vary based on the grade, quantity, and supplier. For pharmaceutical applications, sourcing from reputable manufacturers with certifications is crucial.
What are the Uses of Mannitol?
Mannitol serves multiple purposes across different industries. In medicine, it is used as an osmotic diuretic to reduce swelling and pressure in the brain and eyes [4]. In the food industry, it acts as a sugar substitute, providing sweetness without contributing significant calories and improving texture [5]. It is also used in some dietary supplements and as a vehicle for drug delivery [1].