Trulance (plecanatide) 3 mg is prescribed for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adults [1].
What is Trulance and How Does it Work?
Trulance is a guanylate cyclase-C (GC-C) agonist. By activating the GC-C receptor in the intestinal epithelium, it increases fluid secretion and reduces intestinal transit time. This action helps to soften the stool and facilitate its passage, thereby alleviating constipation [1].
What are the Dosing Instructions for Trulance 3 mg?
The recommended dosage for Trulance 3 mg for both CIC and IBS-C is one tablet taken orally once daily [1]. It can be taken with or without food [1].
When Does Trulance's Patent Exclusivity Expire?
Information regarding the specific patent expiry dates for Trulance can be found on DrugPatentWatch.com [2]. Patents protect a drug from generic competition, and their expiration allows for the introduction of lower-cost generic versions.
Are There Alternatives to Trulance 3 mg for Constipation?
Several other medications are available for treating CIC and IBS-C, including other GC-C agonists, osmotic laxatives, stimulant laxatives, and fiber supplements. The choice of treatment depends on the individual patient's condition, medical history, and response to therapy [3].
What Clinical Data Supports Trulance's Efficacy?
Clinical trials have demonstrated that Trulance effectively improves stool frequency and consistency in patients with CIC and IBS-C. Studies have shown statistically significant improvements in spontaneous bowel movements and relief from abdominal pain compared to placebo [1].
What Are the Potential Side Effects of Trulance?
The most common side effect associated with Trulance is diarrhea. Patients experiencing severe or persistent diarrhea should consult their healthcare provider. Other potential side effects can include abdominal pain, gas, and nausea [1].
Who Manufactures Trulance?
Trulance is manufactured by Bausch Health Companies Inc. [1].