Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the blood. It works by inhibiting an enzyme called HMG-CoA reductase, which is responsible for producing cholesterol in the liver [2].

There is no evidence to suggest that Lipitor impacts fat absorption directly. However, since cholesterol is a type of fat, Lipitor's ability to lower cholesterol levels can indirectly impact fat absorption. By inhibiting HMG-CoA reductase, Lipitor reduces the amount of cholesterol produced in the liver, which in turn reduces the amount of cholesterol that is transported in the bloodstream [2].

One study found that treatment with atorvastatin resulted in a significant reduction in total cholesterol, LDL cholesterol, and triglycerides in patients with hyperlipidemia [3]. Another study showed that atorvastatin treatment was associated with a reduction in the absorption of dietary cholesterol in rats [1].

In conclusion, while there is no direct evidence to suggest that Lipitor impacts fat absorption, its ability to lower cholesterol levels can indirectly impact the absorption of dietary fat. Lipitor's mechanism of action involves inhibiting HMG-CoA reductase, which reduces the amount of cholesterol produced in the liver and transported in the bloodstream [2].

Sources:
[1] https://pubmed.ncbi.nlm.nih.gov/8568017/
[2] https://www.ncbi.nlm.nih.gov/books/NBK430779/
[3] https://www.drugpatentwatch.com/p/tradename/LIPITOR