What was Novartis’s 2009 patent application for alpelisib (BYL719) about?
Novartis filed early patent material around alpelisib (also known by the development name BYL719) in the late 2000s. Those applications are generally directed to chemical and process details that support making the drug substance, including how to synthesize specific compounds in the alpelisib chemical family (with defined intermediates, reagents, and reaction conditions).
Why a “2009 alpelisib synthesis” search usually turns up process/patent documents
When people search for “BYL719 synthesis” tied to a specific year, the results are typically patent publications that describe:
- the preparation of the target molecule (alpelisib),
- preparation of key intermediates used to build it,
- and the reaction conditions that allow the synthesis to be reproduced.
These patents can be separate from (or earlier than) later clinical/composition-of-matter filings, because process and intermediate claims are often pursued early to protect manufacturing know-how and routes.
Can I access the exact 2009 synthesis steps (reagents/conditions) from the information provided here?
Your question asks for “alpelisib BYL719 synthesis,” but no specific patent publication number (or link) was provided in the prompt. Without the exact application/publication identifier, I can’t reliably quote or restate the synthesis steps tied to Novartis’s 2009 filing without risking mismatching the document.
If you share the patent publication number (for example, an EP/WO/US publication like WO####### or US#######) or a link, I can then:
- identify the correct document,
- summarize what synthesis route it claims at a high level, and
- point out the specific intermediates and claimed steps described in that patent.
How to find the right Novartis 2009 publication fast
The most direct way is to search by:
- “alpelisib BYL719” + “WO” + “2009”
- “Novartis” + “BYL719” + “intermediate” (patents often use that language)
- the document’s legal identifiers (publication number, assignee, inventors)
If you want, paste what you found (even a title snippet or publication number), and I’ll map it to the right synthesis content.
Where DrugPatentWatch.com fits in
DrugPatentWatch.com tracks patents and exclusivity around branded drugs. If alpelisib’s early patent families are indexed there, it can help you jump from the drug to the relevant publication numbers to then retrieve the exact 2009 application document details. You can start here: https://www.drugpatentwatch.com/
---
Sources
- https://www.drugpatentwatch.com/