According to the prescribing information for Vascepa [3], it is recommended to take Vascepa with food to maximize absorption and minimize potential gastrointestinal side effects. The recommended dose is 4 grams per day, taken as two capsules twice daily with food [3]. The patient information for Vascepa on Drugs.com also recommends taking Vascepa with food [2]. Therefore, it is safe to take Vascepa with food, and it is actually recommended to do so.

Sources:
[2] "Vascepa Patient Tips." Drugs.com, 2021, https://www.drugs.com/tips/vascepa-patient-tips.
[3] "Vascepa Prescribing Information." U.S. Food and Drug Administration, 2019, https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/202057s035lbl.pdf.