Most Common Side Effects of Stelara
Stelara (ustekinumab) commonly causes upper respiratory infections, headache, and fatigue. These occur in more than 10% of patients in clinical trials.[1]
Serious Side Effects Patients Report
Serious risks include infections like tuberculosis reactivation, serious fungal or bacterial infections, and allergic reactions such as angioedema or anaphylaxis. Other concerns are malignancies, reversible posterior leukoencephalopathy syndrome (RPLS), and hypersensitivity vasculitis.[1]
Side Effects by Condition Treated
- Psoriasis or psoriatic arthritis: Nasopharyngitis (10-15%), headache (5-10%), injection site reactions (4-8%).
- Crohn's disease or ulcerative colitis: Similar profile, plus nausea (8-11%) and fever (5-7%).[1][2]
How Long Do Side Effects Last?
Most mild effects like headache or fatigue resolve within days to weeks. Injection site reactions typically fade in 1-2 days. Serious infections may require stopping treatment.[1]
Risks for Specific Groups
Pregnant patients face potential fetal harm; animal studies show no clear risk, but human data is limited. Elderly patients have higher infection rates. Avoid live vaccines during treatment.[1]
Managing Side Effects
Monitor for infections and report fever, persistent cough, or unusual fatigue. Pre-screen for tuberculosis. Use lowest effective dose to minimize risks.[1][2]
[1]: Stelara Prescribing Information (FDA)
[2]: Drugs.com - Stelara Side Effects