Corlanor, also known as ivabradine, is a medication used to treat symptomatic chronic heart failure [1].
How does Corlanor work for heart failure?
Corlanor works by selectively inhibiting the If current in the sinoatrial node, which is the primary driver of heart rate [1]. By reducing heart rate without affecting contractility or other electrophysiological parameters, it helps to improve symptoms of chronic heart failure [1].
What symptoms does Corlanor address?
Corlanor is indicated for the symptomatic treatment of chronic heart failure with a reduced ejection fraction in adult patients who are in sinus rhythm with a resting heart rate of 75 beats per minute or higher [1].
What are the clinical trial results for Corlanor?
The efficacy of Corlanor was demonstrated in clinical trials such as the SHIFT (Systolic Heart Failure Treatment and மருந்து Trial) study [1]. This trial showed that ivabradine, in addition to standard therapy, reduced the risk of cardiovascular death or non-fatal myocardial infarction in patients with symptomatic chronic heart failure [1].
What are the potential side effects of Corlanor?
Common side effects of Corlanor include bradycardia (slow heart rate), visual disturbances (such as phosphenes, which are luminous phenomena), and hypertension [1]. Patients may also experience atrial fibrillation [1].
What is the regulatory status and approval of Corlanor?
Corlanor has received approval from regulatory bodies such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of chronic heart failure [1].
Are there any contraindications for using Corlanor?
Corlanor should not be used in patients with sick sinus syndrome, sinoatrial (SA) block, or third-degree atrioventricular (AV) block, unless a pacemaker is functioning [1]. It is also contraindicated in patients with resting heart rates below 75 beats per minute, severe hepatic impairment, decompensated heart failure, and those taking certain heart rate-slowing medications [1].
When does Corlanor's patent expire?
Information regarding specific patent expiration dates for Corlanor may be found on resources like DrugPatentWatch.com [2].
Who manufactures Corlanor?
Corlanor is manufactured by Novartis [1].