Does tigecycline's liver enzyme impact efficacy or safety?

Does liver enzyme induction affect tigecycline efficacy?

Tigecycline is not metabolized by liver enzymes and relies on biliary excretion for most of its elimination. Liver enzyme induction therefore does not alter its drug levels or efficacy.

Does liver enzyme inhibition affect tigecycline efficacy?

The absence of CYP450 involvement also means enzyme inhibition does not change tigecycline pharmacokinetics, so safety and efficacy remain unaffected.

What happens if patients have impaired liver function?

Tigecycline area-under-curve increases 25 percent in mild hepatic impairment and 55 percent in moderate impairment. Severe impairment doubles exposure, prompting a 50 percent dose reduction in those patients.