There is no direct scientific evidence to suggest that taking a higher dosage of Advil (ibuprofen) worsens depression. However, it is important to note that non-steroidal anti-inflammatory drugs (NSAIDs) like Advil have been associated with increased risk of mental health issues, including depression, in some studies [1].

A study published in the Journal of Affective Disorders found that regular use of NSAIDs was associated with a higher risk of depression and anxiety [2]. However, this study did not specifically investigate the effects of higher dosages of NSAIDs on depression.

It is also worth noting that Advil is not indicated for the treatment of depression or any mental health disorders. Its primary uses are for the relief of pain, fever, and inflammation [3].

In summary, while there is some evidence linking NSAID use to depression, there is no specific evidence indicating that a higher dosage of Advil worsens depression. If you have concerns about the potential effects of Advil or any other medication on your mental health, it is important to consult with a healthcare professional.

Sources:
[1] <https://www.drugpatentwatch.com/ibuprofen>
[2] <https://www.sciencedirect.com/science/article/abs/pii/S0165032718324133>
[3] <https://www.mayoclinic.org/drugs-supplements/ibuprofen-oral-route/description/drg-20066881>