Does advil pose any risks when combined with mao inhibitors?

What happens if I take Advil with MAO inhibitors?

Taking Advil (ibuprofen) with monoamine oxidase inhibitors (MAOIs) can be risky and potentially life-threatening. MAOIs are a type of antidepressant medication that can interact with Advil and increase the risk of serotonin syndrome, a serious condition that occurs when there's too much serotonin in the body [1].

MAOIs work by blocking the enzyme monoamine oxidase, which breaks down certain substances in the brain, including serotonin. When you take MAOIs, your body can't break down serotonin as quickly, and it builds up in the brain [2]. Advil, on the other hand, increases serotonin levels in the body by blocking an enzyme called prostaglandin synthase [3].

When you take both MAOIs and Advil together, the combination can lead to a massive increase in serotonin levels, causing serotonin syndrome. Symptoms of serotonin syndrome can include:

* Agitation or confusion
* Aggressive behavior
* Sweating
* Rapid heart rate
* High blood pressure
* Nausea and vomiting
* Dilation of pupils
* Loss of consciousness

If you're taking MAOIs and need to take Advil, your doctor may prescribe a lower dose or recommend an alternative pain medication [4]. It's essential to discuss your medication regimen with your doctor before taking Advil or any other pain medication.

Risks associated with MAOIs and Advil

* Increased risk of serotonin syndrome
* Aggravated MAOI-induced side effects, such as anxiety, insomnia, and changes in blood pressure
* Interference with blood pressure-lowering effects of MAOIs [5]

What to do if you're taking MAOIs and need pain relief

* Consult your doctor before taking Advil or any other pain medication
* Ask your doctor about alternative pain-relieving options
* Follow your doctor's advice on dosage and timing of medication
* Monitor your symptoms and report any changes to your doctor

Sources:

[1] DrugPatentWatch.com - Interaction between MAOIs and Advil
[2] Mayo Clinic - Serotonin levels: What you should know
[3] Medical News Today - Ibuprofen (Advil, Motrin)
[4] American Family Physician - Serotonin syndrome: A review
[5] JAMA - Cardiovascular risk factors in patients taking monoamine oxidase inhibitors