Advil is a brand name for ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and reduce fever. According to Drug Patent Watch [1], Advil is metabolized in the liver and excreted through the kidneys. Excessive use of Advil can cause liver damage, especially when combined with alcohol. Alcohol consumption can cause inflammation and damage to the liver, leading to a condition called toxic hepatitis [2]. The combination of Advil and alcohol can increase the risk of liver damage and worsen the symptoms of toxic hepatitis [3].

The liver is a vital organ that performs several functions, including filtering toxins from the blood. Toxic hepatitis is a condition that occurs when the liver is exposed to toxic substances, such as alcohol, drugs, or chemicals, and becomes inflamed and damaged. Symptoms of toxic hepatitis include nausea, vomiting, abdominal pain, fatigue, and jaundice [2].

A study published in the Journal of Clinical and Translational Hepatology [3] found that combining Advil and alcohol can increase the risk of liver damage. The study suggests that the combination of Advil and alcohol can cause oxidative stress and inflammation in the liver, leading to liver damage. The study also found that the risk of liver damage is higher in people who consume alcohol regularly and take Advil frequently.

In conclusion, combining Advil and alcohol can cause liver damage, especially in people who consume alcohol regularly and take Advil frequently. Symptoms of liver damage include nausea, vomiting, abdominal pain, fatigue, and jaundice. If you experience any of these symptoms, you should seek medical attention immediately. It is important to follow the recommended dosage of Advil and avoid consuming alcohol while taking the medication to prevent liver damage.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://www.mayoclinic.org/diseases-conditions/toxic-hepatitis/symptoms-causes/syc-20352202
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7921853/