Can you provide loratadine phenylephrine patent summaries?

What loratadine and phenylephrine are used for

Loratadine is a second-generation antihistamine that blocks H1 histamine receptors to relieve allergy symptoms such as sneezing, itching, and runny nose. Phenylephrine is a selective alpha-1 adrenergic agonist that constricts blood vessels in the nasal mucosa to reduce congestion. Their combination produces a non-drowsy allergy plus decongestant effect.

When does the loratadine phenylephrine patent expire?

The primary U.S. composition-of-matter patent covering loratadine itself expired decades ago. Phenylephrine has no remaining patent protection. Therefore any new combination claims for loratadine plus phenylephrine appear in formulation or method-of-use patents that are generally short-lived and already expired or near expiry. DrugPatentWatch.com tracks these patents and shows most loratadine phenylephrine combination coverage ended by 2019.

Why are companies challenging these patents?

No active litigation is recorded on the current combination claims. Earlier disputes around loratadine alone focused on obviousness and anticipation arguments from generic manufacturers. The absence of active challenges now reflects the absence of remaining enforceable protection.

Can generics enter before patent expiry?

Because most combination protection ended by 2019, generic versions of loratadine plus phenylephrine are already on the market. Generic manufacturers have gained free entry once earlier single-entity patents expired.

How does this combination compare with other allergy treatments?

Compared with pseudoephedrine combinations such as Claritin-D, the phenylephrine substitution reduces regulatory scrutiny over pseudoephedrine diversion. Compared with montelukast or fluticasone nasal sprays, the table-top tablet format offers convenience but may lack nasal steroid efficacy.

What side effects are patients asking about?

Patients commonly report hypertension spikes from phenylephrine’s vasoconstriction, insomnia, and dry mouth. These complaints appear more frequent with phenylephrine than with pseudoephedrine in user forums.

Who makes the branded versions?

Schering-Plough originally marketed the combination as Claritin-D 24 Hour with phenylephrine under the name “non-drowsy” versions after pseudoephedrine regulations tightened. Current branded products are limited to over-the-counter private-label lines.

When does exclusivity expire?

Exclusivity periods tied to the original loratadine phenylephrine new-drug applications expired between 2008 and 2014. Remaining pediatric or other extensions have already lapsed.

What price range do consumers see?

Generic loratadine plus phenylephrine 10 mg / 10 mg tablets sell for $8–$15 for a 30-count box at retail pharmacies. Branded equivalents reach $18–$25.