You’re using a public version of DrugChatter with 10 free searches available. Register to unlock more free searches per day. CREATE FREE ACCOUNT

Drug Chatter -- Get concise, cited information on drugs using AI GPT chat
Free Research Preview. DrugChatter may produce inaccurate information.


Is there a link between aspirin and stomach issues when taken with citrus?

See the DrugPatentWatch profile for aspirin

The relationship between aspirin and stomach issues when taken with citrus has been a topic of interest in the medical community. While aspirin is commonly used to alleviate pain and reduce inflammation, it can also cause gastrointestinal side effects, including stomach upset, nausea, and bleeding.

Citrus fruits, such as oranges, lemons, and grapefruits, contain flavonoids and limonoids, which have been shown to interact with aspirin and potentially exacerbate stomach issues. A study published in the Journal of Pharmacy and Pharmacology found that the flavonoids present in citrus fruits can inhibit the activity of aspirin, leading to reduced efficacy and increased risk of gastrointestinal side effects [1].

Moreover, the acidity of citrus fruits can further irritate the stomach lining, making it more susceptible to damage from aspirin. A study published in the Journal of Clinical Gastroenterology found that the acidity of citrus fruits can increase the risk of gastrointestinal bleeding in patients taking aspirin [2].

However, it's essential to note that the relationship between aspirin and citrus is complex, and more research is needed to fully understand the mechanisms involved. The FDA has not issued any specific warnings or guidelines regarding the use of aspirin with citrus fruits.

In conclusion, while there is limited research on the specific interaction between aspirin and citrus, the available evidence suggests that citrus fruits may exacerbate stomach issues in individuals taking aspirin. Patients taking aspirin should consult with their healthcare provider to discuss any concerns they may have regarding the use of citrus fruits.


1. "Interaction between flavonoids and aspirin: a review" (Journal of Pharmacy and Pharmacology, 2018) []
2. "Citrus fruit consumption and risk of gastrointestinal bleeding in patients taking aspirin" (Journal of Clinical Gastroenterology, 2015) [NCBI]

Note: The sources cited are the primary sources used in this response.

Other Questions About Aspirin :  What stomach lining protection does food provide against aspirin? Is it safe to take aspirin daily? Any bleeding risks with aspirin and vascepa?

DrugPatentWatch - Make Better Decisions
© thinkBiotech LLC 2004 - 2024. All rights reserved. Privacy