Starting dose of eliquis for afib?

What is the starting dose of Eliquis (apixaban) for atrial fibrillation?

For atrial fibrillation (nonvalvular AF), the usual starting dose of Eliquis (apixaban) is 5 mg taken by mouth twice daily.[1]

When is the dose lowered to 2.5 mg twice daily?

The dose is reduced to 2.5 mg by mouth twice daily if a patient has at least 2 of the following criteria:[1]
- Age 80 years or older
- Body weight 60 kg or less
- Serum creatinine 1.5 mg/dL or higher

Does kidney function change the starting dose?

Yes. Kidney function affects dosing through the criteria above (especially serum creatinine). Eliquis dosing for AF is not based on creatinine clearance alone; it uses the age/weight/creatinine criteria to decide between 5 mg BID and 2.5 mg BID.[1]

Is the starting dose the same for “valvular” AF?

Eliquis labeling for AF dosing is for nonvalvular atrial fibrillation. Dosing can differ in other valve-related situations or other indications, so the prescriber should confirm the AF subtype.[1]

Source

[1] https://www.drugs.com/dosage/apixaban.html