Most Common Side Effects of Rinvoq
Rinvoq (upadacitinib), a JAK inhibitor for conditions like rheumatoid arthritis, psoriasis, and ulcerative colitis, commonly causes upper respiratory tract infections (such as colds or sinus infections), nausea, cough, fever, acne, and headache. These affect more than 10% of patients in clinical trials.[1][2]
Side Effects by Body System
- Infections: Nasopharyngitis, bronchitis, and herpes zoster (shingles) occur frequently, with infection rates up to 20-30% higher than placebo.[1]
- Gastrointestinal: Nausea (around 6-11%), abdominal pain, and increased liver enzymes.[2]
- Skin and Musculoskeletal: Acne, rash, and elevated creatine kinase (muscle enzyme) levels, sometimes leading to myalgia.[1]
- Blood and Lab Changes: Anemia, lymphopenia (low white blood cells), and elevated cholesterol.[2]
Serious Risks Patients Search For
Serious side effects include blood clots (deep vein thrombosis or pulmonary embolism), heart-related events (like heart attack), cancers, gastrointestinal tears, and severe infections (e.g., tuberculosis). These are boxed warnings on the label, with risks higher in older patients or those with heart disease risk factors. Monitor for symptoms like leg swelling, chest pain, or persistent fever.[1][2]
How Side Effects Differ by Dose and Condition
Higher doses (15-30 mg) increase risks like infections and lab abnormalities. In atopic dermatitis trials, conjunctivitis was notable (up to 10%); in ulcerative colitis, anemia was more common. Long-term use raises cumulative risks for malignancies and clots.[2]
What to Do If Side Effects Occur
Contact a doctor for persistent infections, unusual fatigue, yellowing skin (liver issues), or blood in stool. Regular blood tests are standard to catch lab changes early. Avoid live vaccines while on Rinvoq.[1]
[1]: Rinvoq Prescribing Information (AbbVie)
[2]: Drugs.com - Rinvoq Side Effects