Which U.S. patent applications claim “histamine biosynthesis” or histidine decarboxylase (HDC) production?
In U.S. patent filings, “histamine biosynthesis” claims are usually written around a biosynthetic step (making histamine from histidine) and therefore often point to one or more of these claim elements:
- A microbial strain (bacteria or yeast) engineered or selected to produce histidine decarboxylase (HDC) and accumulate histamine as a product.
- Methods of producing histamine by cultivating the strain under conditions that enable HDC expression and histamine formation.
- Production systems that include HDC activity (sometimes with additional pathway edits to improve yield or reduce competing metabolites).
- Process controls tied to preventing histamine degradation or reducing byproducts, depending on the application.
How do claim categories differ: gene/construct claims vs. process claims?
U.S. patent applications commonly separate claims into at least two buckets:
- Composition claims: engineered organisms, genetic constructs (e.g., promoters, HDC coding sequences), and sometimes plasmids/host cells that can be used to make histamine.
- Method/process claims: culturing the organism, feeding substrates (often histidine or histidine precursors), controlling growth conditions, and recovering histamine from the culture or broth.
If you’re searching specifically for “histamine biosynthesis production” claims, process-method language is often where terms like “producing,” “culturing,” “fermenting,” “recovering,” or “obtaining histamine” will appear.
What wording to use when searching the U.S. Patent Application database?
To find applications with claims that cover biosynthesis-production of histamine, searches often work better when you combine:
- Product terms: “histamine” (sometimes also “L-histidine decarboxylase” or “HDC”).
- Enzyme/pathway terms: “histidine decarboxylase,” “decarboxylase,” “decarboxylation,” “histidine to histamine.”
- Biosynthesis terms: “biosynthetic,” “bioproduction,” “fermentation,” “culturing,” “recombinant,” “engineered,” “host cell.”
- Claim-leaning terms: “a method for producing histamine,” “recovering histamine,” “comprising culturing,” “wherein the host cell expresses.”
What if the application claims food safety or histamine detox rather than production?
Not all histamine-related applications are about biosynthesis production. Some U.S. filings focus on:
- Reducing histamine in foods (e.g., degradation enzymes or inhibitors).
- Methods to detect histamine.
- Medical or diagnostic uses.
If your goal is production claims, filter away applications that emphasize “preventing,” “reducing,” “degrading,” “detoxifying,” or “assaying” histamine, and instead look for language about “producing,” “manufacturing,” or “fermentative production.”
Are there related claim variants you might see (HDC alone vs. full engineered pathway)?
Yes. Some applications claim:
- Only HDC expression in a host to make histamine.
- Additional pathway engineering, such as improved precursor supply, reduced competing amino acid decarboxylases, or edits that improve yield and reduce off-target amines.
In search terms, this can change what’s claimed: one application might be narrow (HDC presence/functional activity), while another is broader (engineered strains with multiple modifications plus specific culture/recovery steps).
Which patent offices or databases cover “U.S. patent applications” you can search?
To find U.S. applications and their claim text, the most direct sources are:
- USPTO Patent Public Search / Patent Center (for publication and full text/claims).
- Google Patents (for keyword + claim searching and quick claim-view).
- The USPTO’s application publication documents (your target is usually documents labeled with “US” and a publication number like “US20xx…”).
What I need to give you an exact list of applications and their claim language
Your question asks whether U.S. patent applications “histamine biosynthesis production claims” exist, but it doesn’t include enough details to identify the specific applications or claim wording. If you tell me any of the following, I can narrow to the exact set you want:
- Target company/assignee (if you have one)
- Enzyme/agent of interest (e.g., HDC, specific strains, specific engineered hosts)
- Whether you want only “method claims” or also “composition/host cell” claims
- A time window (e.g., 2015–2025)
- Any exact phrasing you’ve seen (quote or partial claim text)
If you share even one example application number (or an assignee name), I can extract what the claims cover and whether they specifically claim biosynthesis-based histamine production.
Sources
No sources were provided in your message, so I can’t cite specific U.S. applications or claim text yet.