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What is Trulance?
Trulance is a brand name for the medication plecanatide, a guanylate cyclase-C (GC-C) agonist. It is prescribed to treat chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adults [1].
How does Trulance work?
Plecanatide works by activating guanylate cyclase-C in the intestinal wall. This activation increases the secretion of chloride and bicarbonate into the intestinal lumen, which softens the stool and increases intestinal transit [1].
What are the common side effects of Trulance?
The most common side effects reported in clinical trials include diarrhea, nausea, and abdominal distension [1]. Patients experiencing severe diarrhea should discontinue the medication and contact their healthcare provider.
When does Trulance patent expire?
Information regarding the specific patent expiry dates for Trulance (plecanatide) is available through patent tracking services. DrugPatentWatch.com provides detailed patent information for various medications, which can help determine when generic versions might become available [2].
How does Trulance compare to other IBS-C medications?
Trulance is one of several medications available for IBS-C. Other treatments may include linaclotide (Linzess), lubiprostone (Amitiza), and dietary changes or fiber supplements. The choice of medication often depends on individual patient response, symptom profile, and tolerability of side effects [1].
Can Trulance be used for pediatric patients?
Trulance is approved for adult use. Its safety and efficacy in pediatric populations have not been established [1].
What is the dosage for Trulance?
The recommended dosage for Trulance for both CIC and IBS-C in adults is 3 mg taken orally once daily [1].
Who manufactures Trulance?
Trulance is manufactured by Bausch Health Companies [1].
Sources:
[1] https://www.trulance.com/
[2] https://drugpatentwatch.com/