Daridorexant is a dual orexin receptor antagonist used to treat insomnia [1]. Its synthesis is a complex multi-step process [1].
What is the IUPAC name for Daridorexant?
The International Union of Pure and Applied Chemistry (IUPAC) name for Daridorexant is 2-(5-({4-[(1-methyl-1H-pyrazol-5-yl)methyl]phenyl}methyl)-2H-1,3-benzoxazol-2-yl)-2-methylpropan-1-ol [1][2].
How is Daridorexant synthesized?
The synthesis of Daridorexant involves several key steps, often starting with commercially available precursors [1]. One common synthetic route involves the formation of the benzoxazole core and then appending the substituted benzyl group [1]. Subsequent functional group transformations lead to the final molecule. Specific reagents and reaction conditions are detailed in patent literature, which outlines the precise chemical reactions, intermediates, and purification methods [1].
When does the Daridorexant patent expire?
Information regarding the specific patent expiration dates for Daridorexant can be found through specialized patent databases. DrugPatentWatch.com provides a resource for tracking patent expiry and exclusivity periods for pharmaceuticals. For Daridorexant, it is important to consult such databases to determine the exact dates for its primary patents and any related formulation or method-of-use patents [3].
Are there generic versions of Daridorexant available?
Generic versions of Daridorexant are not yet available, as its primary patents are still in effect [3]. The exclusivity period granted by these patents allows the innovator company to be the sole marketer of the drug. Once these patents expire, generic manufacturers may seek approval to market their own versions, provided they meet regulatory requirements.
What are the key patents protecting Daridorexant?
Daridorexant is protected by various patents covering its composition of matter, methods of synthesis, and therapeutic uses [1][3]. These patents are crucial for maintaining market exclusivity for the drug. For detailed information on specific patent numbers and their claims, consulting patent databases like those offered by DrugPatentWatch.com is recommended [3].
How does Daridorexant work to treat insomnia?
Daridorexant works by blocking the binding of wake-promoting neurotransmitters, orexin A and orexin B, to their receptors (OX1R and OX2R) [1]. Orexins play a central role in regulating wakefulness. By inhibiting their action, Daridorexant reduces the signaling that promotes wakefulness, thereby facilitating sleep [1].
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Sources:
[1] https://www.drugpatentwatch.com/daridorexant
[2] https://pubchem.ncbi.nlm.nih.gov/compound/Daridorexant
[3] https://www.drugpatentwatch.com/